Chronic active hepatitis in 26 Doberman pinschers

J Am Vet Med Assoc. 1985 Dec 15;187(12):1343-50.


Chronic active hepatitis with increased hepatic copper concentration was diagnosed in 25 female and 1 male Doberman Pinscher dogs. Common clinical signs included polyuria/polydipsia, weight loss, anorexia, icterus, and ascites. Increased liver enzyme activities and abnormal liver function test results were the most consistent clinicopathologic changes. The dogs were assigned to 3 groups on the basis of clinical course of the disease. Group 1 dogs (n = 12) had clinical signs of advanced liver failure and died within one week. Group 2 dogs (n = 7) had less severe clinical signs of liver disease and died within one month. Group 3 dogs (n = 5) did not have clinical signs of illness or had mild clinical signs of liver disease and died 1 to 42 months after initial evaluation. One dog could not be reevaluated and another dog was alive 3 months after initial examination. Treatments consisted of supportive care for dogs in group 1, and dietary manipulations and corticosteroids for dogs in groups 2 and 3. The association of increased liver copper concentration and chronic active hepatitis is not known.

MeSH terms

  • Animals
  • Blood Coagulation
  • Dogs
  • Female
  • Hepatitis, Chronic / blood
  • Hepatitis, Chronic / diagnosis
  • Hepatitis, Chronic / physiopathology
  • Hepatitis, Chronic / veterinary*
  • Hepatitis, Infectious Canine / blood
  • Hepatitis, Infectious Canine / diagnosis*
  • Hepatitis, Infectious Canine / physiopathology
  • Liver / enzymology
  • Liver Function Tests / veterinary
  • Male