Corticosteroid therapy in biliary atresia

J Pediatr Surg. 1985 Dec;20(6):693-5. doi: 10.1016/s0022-3468(85)80026-9.

Abstract

Sixteen patients with biliary atresia had 44 steroid courses for treatment of cholangitis or diminution of bile flow following Kasai hepatic portoenterostomy operations. A "blast" type (high dose/short duration) steroid administration was employed to potentiate the choleretic and anti-inflammatory effect. There was a significant augmentation of bile flow and a reduction in maximum temperature, serum bilirubin, and alkaline phosphatase.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adrenal Cortex Hormones / therapeutic use*
  • Bile / metabolism
  • Bile Ducts / abnormalities*
  • Bilirubin / blood
  • Child, Preschool
  • Cholangitis / drug therapy*
  • Cholangitis / etiology
  • Humans
  • Infant
  • Methods

Substances

  • Adrenal Cortex Hormones
  • Bilirubin