In MASH with moderate or advanced liver fibrosis, weekly semaglutide improved histologic steatohepatitis and fibrosis at 72 wk

Ann Intern Med. 2025 Sep;178(9):JC106. doi: 10.7326/ANNALS-25-03308-JC. Epub 2025 Sep 2.

Abstract

GIM/FP/GP: [Formula: see text] Gastroenterology: [Formula: see text].

MeSH terms

  • Fatty Liver* / drug therapy
  • Fatty Liver* / pathology
  • Female
  • Glucagon-Like Peptide 1
  • Glucagon-Like Peptides* / administration & dosage
  • Glucagon-Like Peptides* / therapeutic use
  • Humans
  • Hypoglycemic Agents* / administration & dosage
  • Hypoglycemic Agents* / therapeutic use
  • Liver Cirrhosis* / drug therapy
  • Liver Cirrhosis* / pathology
  • Male
  • Middle Aged
  • Semaglutide

Substances

  • Glucagon-Like Peptides
  • Hypoglycemic Agents
  • Glucagon-Like Peptide 1
  • Semaglutide