Updates to the CASP Infrastructure in 2024

Proteins. 2026 Jan;94(1):15-24. doi: 10.1002/prot.70042. Epub 2025 Sep 1.

Abstract

CASP (critical assessment of structure prediction) conducts community experiments to determine the state of the art in calculating macromolecular structures. The CASP data management system is continually evolving to address the changing needs of the experiments. For CASP16, we expanded the infrastructure to enable data handling of newly introduced categories and fully support pilot categories introduced in CASP15. This technical note also documents the integration of the CASP and CAPRI (Critical Assessment of PRedicted Interactions) systems.

Keywords: 3D structure prediction; CASP16; RNA structure; alternative conformations; protein structure; protein–ligand complexes.

MeSH terms

  • Computational Biology* / methods
  • Databases, Protein
  • Models, Molecular
  • Protein Conformation
  • Proteins* / chemistry
  • Software*

Substances

  • Proteins