The Mediating Effects of Sleep Quality and Fatigue on Post-Intensive Care Syndrome Among Intensive Care Unit Survivors

Int J Nurs Pract. 2025 Oct;31(5):e70047. doi: 10.1111/ijn.70047.

Abstract

Aims: This study examines the impact of sleep quality in patients during the first week after transfer from the intensive care unit on post-intensive care syndrome, as well as the mediating role of fatigue levels.

Design: A cross-sectional design was employed in a hospital in southern Taiwan.

Methods: One hundred twenty-six intensive care unit survivors were included in the analysis. The outcome measures included a post-intensive care syndrome scale, the Brief Fatigue Inventory-Taiwan, and a 10-point analogue scale for sleep quality. Statistical and hierarchical linear regression methods were used.

Results: The mean score for post-intensive care syndrome was 19.9 (SD = 7.6). The mean score for fatigue levels was 40.4 (SD = 15.5), with 93.7% of participants reporting severe fatigue and significant life interference. The mean score for sleep quality was 5.1 (SD = 3.3). The findings indicated that fatigue was a significant predictor of post-intensive care syndrome, accounting for 78.4% of the variances. Furthermore, fatigue served as a complete mediator in the primary relationship examined in this study.

Conclusion: Study results demonstrate that intensive care survivors experience post-intensive care syndrome, which is negatively correlated with sleep quality and positively correlated with fatigue.

Keywords: fatigue; intensive care unit survivors; post‐intensive care syndrome.

MeSH terms

  • Adult
  • Aged
  • Critical Illness
  • Cross-Sectional Studies
  • Fatigue* / physiopathology
  • Female
  • Humans
  • Intensive Care Units*
  • Male
  • Middle Aged
  • Sleep Quality*
  • Survivors*
  • Taiwan

Supplementary concepts

  • postintensive care syndrome