1 From the Department of Anesthesiology and Pain Management, University of Texas Southwestern Medical Center, Dallas, Texas (GPJ), Department of Anesthesiology, Hospital for Special Surgery/Weill Cornell Medicine, New York, New York, USA (CLW), Anaesthesiology Department, Creta Interclinic Hospital, Hellenic Healthcare Group (HHG), Heraklion, Crete, Greece (EM), University of Leuven, Biomedical Sciences Group, Department of Cardiovascular Sciences, Leuven, Belgium (MVdV), Nottingham Digestive Diseases Centre, Division of Translational Medical Sciences, School of Medicine, University of Nottingham (DNL), National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and University of Nottingham, Queen's Medical Centre (DNL), MRC Versus Arthritis Centre for Musculoskeletal Ageing Research, School of Life Sciences, University of Nottingham, Queen's Medical Centre, Nottingham, UK (DNL), and Division of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA (DNL).