Neoplasia is rarely reported in European hedgehogs (Erinaceus europaeus). A retrospective search was conducted by contacting multiple veterinary diagnostic laboratories for cases of lymphoma in European hedgehogs. This resulted in 5 cases, from which clinical, gross, histologic, and immunophenotyping findings were recorded. Most animals (3/5) had skin masses involving the cervical region, 1 hedgehog had dyspnea and lethargy associated with hydrothorax, whereas another exhibited icterus and lethargy. The primary site of the lymphoma was the skin, particularly the neck or head (3/5), the thymus (1/5), and multicentric (1/5). Immunophenotyping confirmed B-cell lymphoma in 2 skin cases, a T-cell lineage for the thymic and multicentric cases, and undetermined for the remaining skin lymphoma. CD3, PAX5, and CD79a were reliable immunohistochemistry markers in formalin-fixed tissues in European hedgehogs. Although uncommon, lymphoma should be considered in the differential diagnosis for adult European hedgehogs with skin nodules, especially those seeming to originate from the neck.
Keywords: CD3; European hedgehog; hydrothorax; lymphoma; neoplasia; skin nodule; thymus.