A review of prostate cancer focal therapies in general practice

Aust J Gen Pract. 2025 Sep;54(9):654-658. doi: 10.31128/AJGP-12-24-7489.

Abstract

Background: Focal therapy is an emerging treatment modality for prostate cancer that aims to spare patients treatment-related side effects including erectile dysfunction and urinary incontinence associated with surgery and radiotherapy, which are the current standards of care.

Objective: In this narrative review, the authors aim to provide a focused summary of prostate cancer focal therapies for general practice including an overview of key underlying oncological principles, existing treatment modalities, their functional and oncological outcomes, and follow-up after treatment.

Discussion: Focal therapy is being increasingly established in the management of localised prostate cancer and is a promising alternative to surgery and radiotherapy in carefully selected patients. With a growing body of evidence in support of focal therapy, its potential in the future of prostate cancer management is clear.

Publication types

  • Review

MeSH terms

  • Erectile Dysfunction / etiology
  • General Practice / methods
  • General Practice / trends
  • Humans
  • Male
  • Prostatic Neoplasms* / surgery
  • Prostatic Neoplasms* / therapy