Efficacy and safety of prothrombin complex concentrate versus frozen plasma in cardiac surgery: a systematic review and meta-analysis with trial sequential analysis
Br J Anaesth
.
2025 Nov;135(5):1359-1362.
doi: 10.1016/j.bja.2025.07.073.
Epub 2025 Sep 5.
Authors
Laila Shalabi
1
,
Ahmed Ibrahim
2
,
Sofian Zreigh
3
,
Abdelrahman M Tawfik
2
,
Shahed Shalabi
4
,
Mohamed Rifai
5
,
Matthieu Legrand
6
Affiliations
1
Faculty of Medicine, Gharyan University, Gharyan, Libya.
2
Faculty of Medicine, Alexandria University, Alexandria, Egypt.
3
Faculty of Medicine, Ankara Yıldırım Beyazıt University, Ankara, Turkey.
4
College of Pharmacy, Gharyan University, Gharyan, Libya.
5
Faculty of Medicine, Menoufia University, Shebin El Kom, Egypt.
6
Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA, USA. Electronic address: matthieu.legrand@ucsf.edu.
PMID:
40914726
PMCID:
PMC12597385
DOI:
10.1016/j.bja.2025.07.073
No abstract available
Keywords:
cardiac surgery; coagulopathy; frozen plasma; prothrombin complex concentrate.
Publication types
Letter