Management of pregnancy and childbirth in Glanzmann thrombasthenia: A case series and review

Karlijn H G Rutten; Olga Tsiamita; Quentin Van Thillo; Priyanka Raheja; Mandeep Kaler; Karin P M van Galen; Matthew Hogg; Louise Bowles; Roger E G Schutgens; Suthesh Sivapalaratnam

doi:10.1111/bjh.70056

Management of pregnancy and childbirth in Glanzmann thrombasthenia: A case series and review

Br J Haematol. 2025 Oct;207(4):1702-1708. doi: 10.1111/bjh.70056. Epub 2025 Sep 7.

Affiliations

¹ Center for Benign Haematology, Thrombosis and Haemostasis, Van Creveldkliniek, University Medical Centre Utrecht, Utrecht, The Netherlands.
² Department of Clinical Haematology, The Royal London Hospital, Barts Health NHS Trust, London, UK.
³ Department of Thrombosis and Haemostasis, University Hospitals Leuven, Leuven, Belgium.
⁴ Blizard Institute and PHURI, Queen Mary University of London, London, UK.

Abstract

To illustrate the challenges in the management of women with Glanzmann thrombasthenia (GT) planning a pregnancy, we conducted a literature review and present a case series of eight women giving detailed descriptions of reproductive health problems, platelet alloimmunisation, treatment to prevent post-partum haemorrhage and neonatal outcomes. ART, assisted reproductive therapy; PPH, post-partum haemorrhage; rFVIIa, recombinant activated factor VII.

Keywords: FNAIT; Glanzmann thrombasthenia; childbirth; platelet alloimmunisation; pregnancy.

Publication types

Review
Case Reports

MeSH terms

Adult
Factor VIIa / therapeutic use
Female
Humans
Postpartum Hemorrhage / etiology
Postpartum Hemorrhage / prevention & control
Pregnancy
Pregnancy Complications, Hematologic* / therapy
Recombinant Proteins / therapeutic use
Reproductive Techniques, Assisted
Thrombasthenia* / complications
Thrombasthenia* / therapy

Substances

Factor VIIa
recombinant FVIIa
Recombinant Proteins