Corneal argyrosis: histologic, ultrastructural and microanalytic study

Can J Ophthalmol. 1985 Dec;20(7):257-60.

Abstract

The clinical, histopathological, ultrastructural and microanalytic features of a case of iatrogenic ocular argyrosis are reported. The case, in a 63-year-old woman with long-standing herpetic keratitis, was unusual in that it occurred after apparently only one treatment with eyedrops consisting of a 1% solution of "mild silver protein" (Argyrol). Another unusual feature was that the silver deposited in the cornea was mainly conjugated to sulfur; selenium, which commonly demonstrates a high affinity for silver in tissues, was detectable in only trace amounts.

Publication types

  • Case Reports

MeSH terms

  • Argyria / etiology*
  • Argyria / pathology
  • Cornea / analysis
  • Cornea / ultrastructure
  • Corneal Diseases / chemically induced*
  • Corneal Diseases / pathology
  • Female
  • Humans
  • Keratitis, Dendritic / drug therapy
  • Middle Aged
  • Ophthalmic Solutions
  • Self Mutilation
  • Silver Proteins / adverse effects*
  • Silver Proteins / therapeutic use

Substances

  • Ophthalmic Solutions
  • Silver Proteins