Lipoprotein(a) in neoplastic transformation

Clin Chim Acta. 2026 Jan 15:579:120581. doi: 10.1016/j.cca.2025.120581. Epub 2025 Sep 7.

Abstract

Cardiovascular diseases and cancer are top global causes of death, sharing risk factors and treatment strategies. Although dyslipidemia is linked to both, its exact roles are unclear. Recent studies suggest a potential association between plasma lipoprotein(a) levels and cancer risk. This review compiles the latest on lipoprotein(a)'s relation to several cancers and explores potential underlying mechanisms, aiming to deepen understanding of its role in cancer.

Keywords: CVD; Cancer; Clinical evidence; Lipoprotein(a).

Publication types

  • Review

MeSH terms

  • Cell Transformation, Neoplastic* / metabolism
  • Cell Transformation, Neoplastic* / pathology
  • Humans
  • Lipoprotein(a)* / blood
  • Lipoprotein(a)* / metabolism
  • Neoplasms* / blood
  • Neoplasms* / metabolism
  • Neoplasms* / pathology

Substances

  • Lipoprotein(a)