Comparative effectiveness and safety of probiotics with psychotropic potential in mental health benefits in irritable bowel syndrome: a systematic review and network meta-analysis

Eur J Gastroenterol Hepatol. 2026 Jan 1;38(1):27-35. doi: 10.1097/MEG.0000000000003062. Epub 2025 Aug 25.

Abstract

Background: The use of probiotics as a treatment for irritable bowel syndrome (IBS) is gaining attention, with recent studies indicating that certain probiotics or combinations may have mental health benefits for patients with IBS.

Aims: To systematically review and meta-analyze, using network meta-analysis (NWM), the comparative effectiveness and safety of probiotics with psychotropic potential on quality of life, depression, and anxiety in patients with IBS.

Methods: Relevant randomized controlled trials (RCTs) were analyzed, using a Bayesian NWM, to compare the performance of probiotics with mental health benefits in IBS treatment. Treatment effectiveness was assessed using surfaces under cumulative ranking (SUCRA) values.

Results: The analysis included 3154 participants assigned to nine different treatments: Bifidobacterium longum, Saccharomyces, Clostridium butyricum, Bifidobacterium lactis, Lactobacillus acidophilus, Lactobacillus casei strain Shirota, Lactobacillus plantarum, probiotic combinations, and placebo. B. longum and probiotic combinations were found to be significantly more effective than placebo. In terms of improving quality of life (QoL), B. longum was the most effective (SUCRA = 89.7%), while L. plantarum was the least effective (SUCRA = 14.9%). For alleviating depression and anxiety, the combination of probiotics (SUCRA = 95.6%) and L. acidophilus (SUCRA = 74.2%) showed the best results, respectively.

Conclusion: Some probiotics or combinations may offer benefits for patients with IBS in improving QoL, depression, and anxiety; however, as this is a developing field, additional research is necessary to fully understand the effectiveness, underlying mechanisms, and specific strains that may be advantageous. More high-quality RCTs are needed to substantiate these therapeutic possibilities.

Keywords: efficacy; irritable bowel syndrome; network meta-analysis; probiotics; psychobiotics.

Publication types

  • Systematic Review
  • Network Meta-Analysis

MeSH terms

  • Anxiety* / diagnosis
  • Anxiety* / psychology
  • Anxiety* / therapy
  • Depression* / diagnosis
  • Depression* / psychology
  • Depression* / therapy
  • Humans
  • Irritable Bowel Syndrome* / diagnosis
  • Irritable Bowel Syndrome* / microbiology
  • Irritable Bowel Syndrome* / psychology
  • Irritable Bowel Syndrome* / therapy
  • Mental Health*
  • Probiotics* / adverse effects
  • Probiotics* / therapeutic use
  • Psychotropic Drugs* / adverse effects
  • Psychotropic Drugs* / therapeutic use
  • Quality of Life
  • Randomized Controlled Trials as Topic
  • Treatment Outcome

Substances

  • Psychotropic Drugs