Perturbing neural stem cell fate in glioblastoma heterogeneity and beyond

Ethan W Hollingsworth; Jaime Imitola

doi:10.1016/j.stemcr.2025.102633

Perturbing neural stem cell fate in glioblastoma heterogeneity and beyond

Stem Cell Reports. 2025 Sep 9;20(9):102633. doi: 10.1016/j.stemcr.2025.102633.

Authors

Ethan W Hollingsworth¹, Jaime Imitola²

Affiliations

¹ Medical Scientist Training Program, Irvine, CA 92697, USA; Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA 92697, USA.
² Laboratory of Neural Stem Cells and Functional Neurogenetics, Farmington, CT 06030, USA; Departments of Neuroscience, Neurology, Genetics and Genome Sciences, UConn Health, Farmington, CT 06030, USA. Electronic address: imitola@uchc.edu.

Abstract

Intratumoral heterogeneity in glioblastoma is thought to underlie its remarkable ability to recur and resist therapies. Its origins, however, remain unknown. In this issue, Liu et al. model the contributions of cell-of-origin and genetic drivers to intratumoral heterogeneity in glioblastoma, using a perturbation paradigm with broad neurodevelopmental applications.

MeSH terms

Animals
Brain Neoplasms* / genetics
Brain Neoplasms* / pathology
Cell Differentiation
Cell Lineage*
Genetic Heterogeneity
Glioblastoma* / genetics
Glioblastoma* / pathology
Humans
Neoplastic Stem Cells / pathology
Neural Stem Cells* / metabolism
Neural Stem Cells* / pathology