How should race be best considered in understanding brain-behavior relationships? Implications for understanding onset of engagement in addictive behaviors and subsequent problems

J Behav Addict. 2025 Sep 10;14(3):1124-1128. doi: 10.1556/2006.2025.00077. Print 2025 Sep 30.

Abstract

Developmental onset has been linked to addictive problems and severity, including for behavioral addictions like gambling disorder. Individual differences associated with race have been linked to addictive behaviors and disorders in complex manners. Race is understood as a multidimensional construct encompassing biological and social influences. This raises questions about how race should be conceptualized and modeled in brain-behavior relationship studies relevant to addictive behaviors and disorders. Here, we consider two recent publications involving early initiation of substance use (EISU). They derive potentially different conclusions, perhaps in part relating to how race and ethnicity were considered in analyses. Implications for behavioral addictions are explored.

Keywords: addictive behaviors; adolescence; early initiation; genetics; race; substance use.

Publication types

  • Review

MeSH terms

  • Behavior, Addictive* / ethnology
  • Behavior, Addictive* / physiopathology
  • Behavior, Addictive* / psychology
  • Brain* / physiopathology
  • Gambling / ethnology
  • Gambling / physiopathology
  • Humans
  • Racial Groups* / psychology
  • Substance-Related Disorders* / ethnology
  • Substance-Related Disorders* / physiopathology