Chemical stabilities of cefamandole nafate and metronidazole when mixed together for intravenous infusion

J Clin Hosp Pharm. 1985 Dec;10(4):379-83. doi: 10.1111/j.1365-2710.1985.tb00937.x.

Abstract

The chemical stabilities of cefamandole nafate and metronidazole, when mixed together for intravenous infusion, have been studied using a stability-indicating, high-performance liquid chromatographic method of assay. Cefamandole nafate was stable for 5 days at 25 degrees C and at least 14 days at 5 degrees C. The addition of metronidazole did not affect the stability of cefamandole nafate. In a 2% solution of cefamandole in metronidazole injection (0.5%), metronidazole lost about 9.1% of potency in less than 2 h at 25 degrees C and in less than 6 h at 5 degrees C. The per cent loss was directly related to the initial concentration of cefamandole nafate. Change in the concentration of metronidazole did not affect the per cent of metronidazole lost.

MeSH terms

  • Cefamandole / administration & dosage
  • Cefamandole / analogs & derivatives*
  • Cefamandole / analysis
  • Chromatography, High Pressure Liquid
  • Drug Combinations
  • Drug Stability
  • Infusions, Parenteral
  • Metronidazole / administration & dosage
  • Metronidazole / analysis*

Substances

  • Drug Combinations
  • Metronidazole
  • Cefamandole
  • cefamandole nafate