mtDNA base editing: Mind the gap

Jose Domingo Barrera-Paez; Carlos T Moraes

doi:10.1016/j.molcel.2025.08.028

mtDNA base editing: Mind the gap

Mol Cell. 2025 Sep 18;85(18):3351-3352. doi: 10.1016/j.molcel.2025.08.028.

Authors

Jose Domingo Barrera-Paez¹, Carlos T Moraes²

Affiliations

¹ MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.
² Deptartment of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA. Electronic address: cmoraes@med.miami.edu.

PMID: 40972522
DOI: 10.1016/j.molcel.2025.08.028

Abstract

In this issue of Molecular Cell, Xiang et al.¹ provided insights into the mechanism and structure-guided engineering of DdCBE for mitochondrial DNA base editing. More precise editing was achieved by better defining the editing window.

Publication types

Comment

MeSH terms

DNA, Mitochondrial* / genetics
DNA, Mitochondrial* / metabolism
Gene Editing*
Humans
Mitochondria* / genetics

Substances

DNA, Mitochondrial