Personalized Thyroidology: Molecular Rewiring of Thyroid Nodule Management

Clin Cancer Res. 2025 Dec 1;31(23):4869-4871. doi: 10.1158/1078-0432.CCR-25-2474.

Abstract

Multigene molecular testing panels demonstrated excellent performance characteristics for the evaluation of indeterminate thyroid nodules and independently risk-stratified advanced tumor stage in the Chinese population. Findings support incorporating cost-conscious molecular diagnostics in an integrated pathway along with clinical, sonographic, and cytologic features while underscoring the need for prospective validation in future studies. See related article by Ding et al., p. 4996.

MeSH terms

  • Biomarkers, Tumor* / genetics
  • Disease Management
  • Humans
  • Molecular Diagnostic Techniques
  • Precision Medicine* / methods
  • Thyroid Neoplasms* / diagnosis
  • Thyroid Neoplasms* / genetics
  • Thyroid Nodule* / diagnosis
  • Thyroid Nodule* / genetics
  • Thyroid Nodule* / pathology
  • Thyroid Nodule* / therapy

Substances

  • Biomarkers, Tumor