Temporal dedifferentiation of neural states with age during naturalistic viewing

Commun Biol. 2025 Sep 30;8(1):1390. doi: 10.1038/s42003-025-08792-4.

Abstract

While life is experienced continuously, we perceive it as a series of events. At a neural level, this event segmentation process has been linked to changes in neural states. An open question is whether neural states differ with age. Participants (N = 577) from the CamCAN cohort viewed an 8-min movie during functional magnetic resonance imaging. A data-driven state segmentation method was used to identify neural state changes. To study the effects of age, participants were sorted into 34 age groups. We show that neural states become significantly longer with increasing age, particularly in visual and ventromedial prefrontal cortices. Event boundaries overlapped with state changes in superior temporal and dorsomedial prefrontal regions, but there was no effect of age on this relationship. Our results suggest reduced temporal differentiation of successive neural states with increasing age. Nevertheless, preserved alignment between neural states and perceived events suggests coarse event segmentation remains intact.

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Aged
  • Aging* / physiology
  • Brain Mapping
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Prefrontal Cortex* / diagnostic imaging
  • Prefrontal Cortex* / physiology
  • Visual Perception* / physiology
  • Young Adult