Digital hypertension - what we need for the high-quality management of hypertension in the new era

Kazuomi Kario; Kei Asayama; Hisatomi Arima; Chisa Matsumoto; Naoki Nakagawa; Akihiro Nomura; Michihiro Satoh; Keisuke Shinohara; Naoko Tomitani; Koichi Yamamoto; Satoshi Hoshide; JSH Working Group on new technology and BP monitoring systems for better management of hypertension

doi:10.1038/s41440-025-02307-8

Digital hypertension - what we need for the high-quality management of hypertension in the new era

Hypertens Res. 2025 Sep 30. doi: 10.1038/s41440-025-02307-8. Online ahead of print.

Authors

Kazuomi Kario¹, Kei Asayama^{2

3

4}, Hisatomi Arima⁵, Chisa Matsumoto^{6

7}, Naoki Nakagawa⁸, Akihiro Nomura^{9

10

11}, Michihiro Satoh^{12

13

14}, Keisuke Shinohara¹⁵, Naoko Tomitani¹⁶, Koichi Yamamoto¹⁷, Satoshi Hoshide¹⁶; JSH Working Group on new technology and BP monitoring systems for better management of hypertension

Affiliations

¹ Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, Japan. kkario@jichi.ac.jp.
² Department of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan.
³ KU Leuven Department of Public Health and Primary Care, University of Leuven, Leuven, Belgium.
⁴ Tohoku Institute for Management of Blood Pressure, Sendai, Japan.
⁵ Department of Preventive Medicine & Public Health, Fukuoka University, Fukuoka, Japan.
⁶ Center for Health Surveillance & Preventive Medicine, Tokyo Medical University Hospital, Tokyo, Japan.
⁷ Department of Cardiology, Tokyo Medical University, Tokyo, Japan.
⁸ Division of Cardiology and Nephrology, Department of Internal Medicine, Asahikawa Medical University, Asahikawa, Japan.
⁹ College of Transdisciplinary Sciences for Innovation, Kanazawa University, Kanazawa, Japan.
¹⁰ Department of Cardiovascular Medicine, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan.
¹¹ Frontier Institute of Tourism Sciences, Kanazawa University, Kanazawa, Japan.
¹² Division of Public Health, Hygiene and Epidemiology, Tohoku Medical and Pharmaceutical University, Sendai, Japan.
¹³ Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
¹⁴ Department of Pharmacy, Tohoku Medical and Pharmaceutical University Hospital, Sendai, Japan.
¹⁵ Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.
¹⁶ Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, Japan.
¹⁷ Department of Geriatric and General Medicine, Graduate School of Medicine, The University of Osaka, Osaka, Japan.

PMID: 41028224
DOI: 10.1038/s41440-025-02307-8

Abstract

Digital technologies are playing an increasing role in hypertension management. Digital hypertension is a new field that integrates advancing technologies into hypertension management. This research area encompasses various aspects of digital transformation technologies, including the development of novel blood pressure (BP) measurement devices-whether cuffless or cuff-based sensors-the transmission of large-scale time-series BP data, cloud-based computing and analysis of BP indices, presentation of the results, and feedback systems for both patients and physicians. A key component of this approach is novel blood pressure (BP) monitoring devices. This article summarizes the latest information and discussions about "held at the 2024 Japan Society of Hypertension scientific meeting. Novel BP monitoring includes cuffless devices that estimate BP, but cuffless devices require achieving accuracy without the need for calibration using conventional cuff-based devices. New BP monitoring devices can provide information on novel biomarkers beyond BP and may improve risk assessment and outcomes. Integration of BP data with omics and clinical information should enable personalized hypertension management. Key data gaps relating to novel BP monitoring devices are accuracy/validation in different settings/populations, association between BP metrics and hard clinical outcomes, and measurement/interpretation of BP variability data. Human- and health system-related factors also need to be addressed or overcome before these devices can be successfully integrated into routine clinical practice. If these things can be achieved, new BP monitoring technologies could transform hypertension management and play a pivotal role in the future of remote healthcare. This article summarizes the latest information and discussions about digital hypertension from the Digital Hypertension symposium that took place during the 2024 Japan Society of Hypertension scientific meeting.

Keywords: Artificial intelligence; Cuffless blood pressure monitoring; Device validation; Digital hypertension; Wearable blood pressure monitoring.

Publication types

Review