Pathogenic mechanisms and treatment advances in proliferative vitreoretinopathy: A review

Abstract

Proliferative vitreoretinopathy (PVR) is the most common cause of repair failure in rhegmatogenous retinal detachment and a severe complication of posterior segment penetrating injuries. The pathogenesis of PVR is complex, and there is currently no ideal therapeutic drug in clinical practice. Surgical intervention involves the removal of proliferative membranes to relieve traction on the retina, but it carries a certain postoperative recurrence rate. This review provides an overview of the pathogenesis and treatment strategies for PVR.

Keywords: cells; inflammatory mediators; pathways; proliferative vitreoretinopathy.