[Treatment of pediatric chronic myeloid leukemia]

Rinsho Ketsueki. 2025;66(9):1241-1251. doi: 10.11406/rinketsu.66.1241.
[Article in Japanese]

Abstract

Treatment strategies for chronic myeloid leukemia (CML) have changed significantly with the development of new tyrosine kinase inhibitors (TKIs). Due to its extreme rarity, pediatric CML has historically been managed based on evidence in adult patients. However, as the unique biological and clinical characteristics of pediatric CML have become increasingly apparent, the need for pediatric-specific treatment guidelines is now widely recognized. This review outlines the treatment of pediatric CML as of 2025, with a focus on clinical trial results from Japan and the latest consensus guidelines issued by the International Pediatric CML Working Group.

Keywords: Chronic myeloid leukemia; Pediatric CML; Tyrosine kinase inhibitors.

Publication types

  • Review
  • English Abstract

MeSH terms

  • Antineoplastic Agents / therapeutic use
  • Child
  • Clinical Trials as Topic
  • Humans
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive* / drug therapy
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive* / genetics
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive* / therapy
  • Practice Guidelines as Topic
  • Protein Kinase Inhibitors / therapeutic use

Substances

  • Protein Kinase Inhibitors
  • Antineoplastic Agents