Aminoquinoline-Directed Electrochemical Cobalt-Catalyzed C(sp²)-H Alkoxylation

J Org Chem. 2025 Oct 10;90(40):14118-14131. doi: 10.1021/acs.joc.5c01585. Epub 2025 Oct 2.

Abstract

Electrochemically, earth-abundant cobalt(II)-catalyzed C(sp2)-H alkoxylation of ferrocenyl and arenyl amides with 8-aminoquinoline directing groups was developed under mild, oxidant-free conditions. This protocol afforded a broad range of alkoxylated products in moderate to high yields, employing readily available alcohols as both alkoxy sources and green solvents. Notably, this method enabled efficient C-O bond formation via sustainable electrolysis and offered a practical route to alkylated organic compounds.