Synthesis of (P^N^C)Gold(III) Complexes via Tandem Oxidative Addition/C-H Auration

Michał Biedrzycki; Jaime Martín; Alexandre Genoux; Elia Boschi; Cristina Nevado

doi:10.1021/acsorginorgau.5c00057

Synthesis of (P^N^C)Gold(III) Complexes via Tandem Oxidative Addition/C-H Auration

ACS Org Inorg Au. 2025 Aug 23;5(5):322-327. doi: 10.1021/acsorginorgau.5c00057. eCollection 2025 Oct 1.

Authors

Michał Biedrzycki¹, Jaime Martín¹, Alexandre Genoux¹, Elia Boschi¹, Cristina Nevado¹

Affiliation

¹ Department of Chemistry, University of Zurich, Winterthurerstrasse 190, Zurich CH 8057, Switzerland.

Abstract

A new method for the synthesis of cyclometalated gold-(III) complexes featuring (P^N^C) ligands is reported. This protocol employs a tandem oxidative addition/cycloauration process, enabling the formation of (P^N^C)-gold-(III)-aryl, -alkenyl and -alkynyl derivatives by creating two Au-C bonds in one pot from a structurally diverse range of C-(sp²)- and C-(sp)-iodide substrates. Additionally, a complementary two-step method was developed to access (P^N^C)-gold-(III)-alkynyl complexes, which exhibit emission in the blue and green light regions.

Keywords: cyclometalation; gold; ligands; oxidative addition; phosphorescence.