Maintenance and Reliever Therapy in Pediatric Asthma: A Concise Review of Recent Evidence-Part I

Pediatr Ann. 2025 Oct;54(10):e367-e371. doi: 10.3928/19382359-20250828-07. Epub 2025 Oct 1.

Abstract

Pediatric asthma is a chronic inflammatory respiratory condition characterized by recurrent wheezing, chest tightness, breathlessness, and coughing, which can significantly impact quality of life and lead to hospitalization or long-term lung impairment. The prevalence of asthma has increased globally, with higher rates in urban areas and developing countries. Current management strategies emphasize inhaled corticosteroids (ICS) as the cornerstone of treatment, with long-acting beta 2-agonists (LABAs) introduced for patients requiring additional symptom control. ICS-LABA combinations have demonstrated efficacy in reducing exacerbations, improving lung function, and lowering health care utilization. However, concerns persist regarding adherence, potential masking of airway inflammation, and optimal dosing. The emerging maintenance and reliever therapy (MART) approach integrates ICS and formoterol into a single inhaler for both maintenance and symptom relief, aiming to enhance adherence and optimize treatment outcomes. This review examines the current evidence supporting ICS-LABA therapy and introduces MART as a potential alternative for pediatric asthma management.

Publication types

  • Review

MeSH terms

  • Administration, Inhalation
  • Adrenal Cortex Hormones* / administration & dosage
  • Adrenal Cortex Hormones* / therapeutic use
  • Adrenergic beta-2 Receptor Agonists* / administration & dosage
  • Adrenergic beta-2 Receptor Agonists* / therapeutic use
  • Anti-Asthmatic Agents* / administration & dosage
  • Anti-Asthmatic Agents* / therapeutic use
  • Asthma* / drug therapy
  • Child
  • Humans

Substances

  • Anti-Asthmatic Agents
  • Adrenal Cortex Hormones
  • Adrenergic beta-2 Receptor Agonists