Longevity steps on the cGAS

Science. 2025 Oct 9;390(6769):126-127. doi: 10.1126/science.aeb6125. Epub 2025 Oct 9.

Authors

John C Martinez¹, Andrei Seluanov^{1

2}, Vera Gorbunova^{1

2}

Affiliations

¹ Department of Biology, University of Rochester, Rochester, NY, USA.
² University of Rochester Medical Center, Rochester, NY, USA.

PMID: 41066590
DOI: 10.1126/science.aeb6125

Abstract

A DNA repair function in a cytosolic sensor demonstrates a potential role in naked mole-rat longevity.

Publication types

Comment

MeSH terms

Animals
Cytosol / metabolism
DNA Repair*
Longevity* / genetics
Mole Rats* / genetics
Mole Rats* / physiology
Nucleotidyltransferases* / genetics
Nucleotidyltransferases* / metabolism

Substances

Nucleotidyltransferases