Primary bladder signet ring cell adenocarcinoma in a young male with Lynch Syndrome

James Um; Aidan Kennedy; Christopher D Jaeger; Nikta Rezakahn Khajeh; Paul Alan Horning; Reenal Patel; Kanika Arora; Adam J Gadzinski

doi:10.1016/j.eucr.2025.103223

Primary bladder signet ring cell adenocarcinoma in a young male with Lynch Syndrome

Urol Case Rep. 2025 Sep 24:63:103223. doi: 10.1016/j.eucr.2025.103223. eCollection 2025 Nov.

Authors

James Um¹, Aidan Kennedy¹, Christopher D Jaeger¹, Nikta Rezakahn Khajeh¹, Paul Alan Horning¹, Reenal Patel¹, Kanika Arora¹, Adam J Gadzinski¹

Affiliation

¹ Department of Urology, Corewell Health William Beaumont University, Royal Oak, MI, United States of America.

Abstract

A 32-year-old male with Lynch Syndrome and a history of colon cancer status post total proctocolectomy was found to have invasive high-grade carcinoma with signet ring cell morphology on tissue sampling of the bladder neck following transurethral resection of a bladder tumor (TURBT). The patient subsequently underwent an open cystoprostatectomy and completion proctectomy. Final pathology of the prostate, bladder, and bladder augment confirmed the diagnosis of signet ring cell adenocarcinoma (SRCC) of the bladder. Given its rarity, this case illustrates the challenges of managing an aggressive bladder cancer and underscores the importance of considering appropriate screening strategies in high-risk populations.

Keywords: Bladder cancer; Case report; Lynch syndrome; Signet ring cell carcinoma.

Publication types

Case Reports