Efficacy and safety of 570/590 Nm yellow light combined with red light and infrared LED in treating facial skin photoaging: A Single-Center, randomized Controlled, exploratory study

Abstract

This study compared the efficacy of 570 nm and 590 nm yellow light, combined with red light and infrared LED phototherapy, in treating facial skin photoaging. Thirty patients with skin photoaging were enrolled between December 2024 and January 2025 and randomly assigned to two groups: the 570 nm combined LED group (hereafter referred to as the 570 group) and the 590 nm combined LED group (hereafter referred to as the 590 group), with 15 patients in each. The 570 group received treatment using 570 nm yellow light, 620 nm red light, and 850 nm infrared light (power density: 7.1 mW/cm²; total energy: 6.39 J/cm²), while the 590 group was treated with 590 nm yellow light alongside the same red and infrared wavelengths and identical parameters. Treatments were administered three times weekly for 8 weeks. GSP scores and VISIA skin imaging analyzer assessments (pores, wrinkles, texture, brown spots) were recorded pre- and post-treatment. Twenty-eight subjects (93.3%) completed the study. After 8 weeks, the 570 group showed significant reductions in GSP scores, wrinkle scores, and brown spot scores compared to baseline (P < 0.05). The 590 group also demonstrated reductions in GSP and wrinkle scores (P < 0.05). The difference in wrinkle scores between the two groups post-treatment was statistically significant (P < 0.05). Both 570 nm and 590 nm yellow light, combined with red light and infrared LED therapy, effectively reduce pores, wrinkles, texture, and brown spots, improving skin photoaging. The 570 nm yellow composite LED treatment showed more significant effects on both facial wrinkles and brown spots.

Keywords: 570 nm yellow light; 590 nm yellow light; Light emitting diode (LED); Skin photoaging.