Bilateral Sudden on Chronic Hearing Loss as an Auditory Manifestation of Mitochondrial DNA Mutations

Laryngoscope. 2026 Mar;136(3):1495-1499. doi: 10.1002/lary.70208. Epub 2025 Oct 17.

Abstract

We presented a series of patients with a mitochondrial DNA mutation who presented to our clinic with sudden bilateral sudden on chronic sensorineural hearing loss; these patients responded well to cochlear implantation. In cases of sudden sensorineural hearing loss-particularly when clinical features raise suspicion for an underlying mitochondrial disorder-genetic testing may offer valuable diagnostic insight and assist in guiding appropriate management strategies.

Keywords: genetic testing; mitochondrial DNA mutations; sudden hearing loss.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Chronic Disease
  • Cochlear Implantation
  • DNA, Mitochondrial* / genetics
  • Female
  • Hearing Loss, Bilateral* / diagnosis
  • Hearing Loss, Bilateral* / genetics
  • Hearing Loss, Bilateral* / surgery
  • Hearing Loss, Sensorineural* / diagnosis
  • Hearing Loss, Sensorineural* / genetics
  • Hearing Loss, Sensorineural* / surgery
  • Hearing Loss, Sudden* / diagnosis
  • Hearing Loss, Sudden* / genetics
  • Hearing Loss, Sudden* / surgery
  • Humans
  • Male
  • Middle Aged
  • Mutation*

Substances

  • DNA, Mitochondrial