Don't forget to floss! An innovative approach for vaccine delivery

Heather D Hickman; Niki M Moutsopoulos

doi:10.1016/j.cell.2025.09.008

Don't forget to floss! An innovative approach for vaccine delivery

Cell. 2025 Oct 16;188(21):5787-5789. doi: 10.1016/j.cell.2025.09.008.

Authors

Heather D Hickman¹, Niki M Moutsopoulos²

Affiliations

¹ Viral Immunity and Pathogenesis Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: hhickman@niaid.nih.gov.
² Human Barrier Immunity Section, Laboratory of Host Immunity and Microbiome, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: niki.moutsopoulos@nih.gov.

PMID: 41106358
DOI: 10.1016/j.cell.2025.09.008

Abstract

In a recent issue of Nature Biomedical Engineering, Ingrole et al. explore a new approach for needle-free vaccine delivery through the mouth. They devise and test a dental-floss-based flu vaccine as an alternative mode of mucosal vaccination.

Published by Elsevier Inc.

MeSH terms

Drug Delivery Systems* / methods
Humans
Influenza Vaccines* / administration & dosage
Influenza Vaccines* / immunology
Influenza, Human* / prevention & control
Vaccination* / methods

Substances

Influenza Vaccines