TFOS DEWS III

James S Wolffsohn; José Benítez-Del-Castillo; Denise Loya-Garcia; Takenori Inomata; Geetha Iyar; Lingyi Liang; Heiko Pult; Alfonso L Sabater; Christopher E Starr; Jelle Vehof; MichaelT M Wang; Wei Chen; Jennifer P Craig; Murat Dogru; Victor L Perez Quinones; Fiona Stapleton; David A Sullivan; Lyndon Jones; TFOS 合作者小组

doi:10.1016/j.ajo.2025.10.018

TFOS DEWS III

Am J Ophthalmol. 2025 Oct 18:S0002-9394(25)00554-9. doi: 10.1016/j.ajo.2025.10.018. Online ahead of print.

Authors

James S Wolffsohn¹, José Benítez-Del-Castillo², Denise Loya-Garcia³, Takenori Inomata⁴, Geetha Iyar⁵, Lingyi Liang⁶, Heiko Pult⁷, Alfonso L Sabater⁸, Christopher E Starr⁹, Jelle Vehof¹⁰, MichaelT M Wang¹¹, Wei Chen¹², Jennifer P Craig¹¹, Murat Dogru¹³, Victor L Perez Quinones⁸, Fiona Stapleton¹⁴, David A Sullivan¹⁵, Lyndon Jones¹⁶; TFOS 合作者小组

Collaborators

TFOS 合作者小组:
Reiko Arita¹⁷, Carlos Belmonte¹⁸, Robin L Chalmers¹⁹, Anat Galor²⁰, Ghosh Arkasubhra²¹, Marc Labetoulle²², Kelly K Nichols²³, Andrew D Pucker²⁴, Eduardo M Rocha²⁵, Benjamin Sullivan²⁶, Piera Versura²⁷, Mark D P Willcox²⁸

Affiliations

¹ From the Optometry and Vision Science, College of Health and Life Sciences, Aston University, Birmingham, UK. Electronic address: J.s.w.wolffsohn@aston.ac.uk.
² University Complutense, Hospital Clinico San Carlos, Clinica Rementeria, Madrid, Spain.
³ Instituto de Oftalmología Fundación de Asistencia Privada Conde de Valenciana, I.A.P, Mexico City, Mexico; Tecnologico de Monterrey, School of Medicine and Health Sciences, Monterrey, Mexico.
⁴ Department of Ophthalmology, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo, Japan.
⁵ CJ Shah Cornea Services/Dr G Sitalakshmi Memorial Clinic for Ocular Surface Disorders, Medical Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu, India.
⁶ State key laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
⁷ College of Biomedical & Life Sciences, Optometry & Vision Sciences, Cardiff University, UK; Dr. Heiko Pult - Optometry and Vision Research, Weinheim, Germany.
⁸ Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
⁹ Weill Cornell Medicine, New York-Presbyterian Hospital, New York, NY.
¹⁰ Department of Ophthalmology and Epidemiology, University of Groningen, Groningen, the Netherlands; Department of Ophthalmology, Vestfold Hospital Trust, Tønsberg, Norway.
¹¹ Department of Ophthalmology, New Zealand National Eye Centre, The University of Auckland, Auckland, New Zealand.
¹² Eye Hospital of Wenzhou Medical University, National Eye Clinic Research Center, PR China.
¹³ Ichikawa General Hospital Tokyo Dental College Dept of Ophthalmology Ichikawa, Chiba, Japan.
¹⁴ School of Optometry and Vision Science, UNSW Sydney, NSW, Australia.
¹⁵ Tear Film & Ocular Surface Society, Boston, USA.
¹⁶ Centre for Ocular Research & Education (CORE), School of Optometry and Vision Science, University of Waterloo, Waterloo, ON, Canada.
¹⁷ Itoh Clinic, University of Tokyo, Japan. Electronic address: ritoh@za2.so-net.ne.jp.
¹⁸ Instituto de Neurociencias, Universidad Miguel Hernández-CSIC, Avda Santiago Ramón y Cajal s/n, Alicante, Spain. Electronic address: carlos.belmonte@umh.es.
¹⁹ Clinical Trial Consultant, Atlanta, Georgia, USA. Electronic address: chalmers2097@gmail.com.
²⁰ Miami Veterans Affairs Medical Center Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Florida, USA. Electronic address: AGalor@med.miami.edu.
²¹ Molecular Signalling and Gene Therapy, GROW laboratory, Narayana Nethralaya Foundation (nnf.org.in), Bangalore, India. Electronic address: Arkasubhra@narayananethralaya.com.
²² Ophthalmology Department, Bicêtre Hôpital, APHP, Paris-Saclay niversity, Kremlin-Bicêtre, France; Quinze-Vingts Hospital, Paris, France. Electronic address: marc.labetoulle@aphp.fr.
²³ School of Optometry, The University of Alabama at Birmingham, Alabama, USA. Electronic address: nicholsk@uab.edu.
²⁴ Eminent Ophthalmic Services, Milledgeville, Georgia, USA. Electronic address: apucker@uab.edu.
²⁵ Dept of Ophthalmology, Otorhinolaryngology and Head & Neck Surgery Ribeirao Preto Medical School, University of Sao Paulo, Brazil. Electronic address: emrocha@fmrp.usp.br.
²⁶ Bausch & Lomb, Bridgewater, New Jersey, USA; Lμbris BioPharma, Florida, USA. Electronic address: bdsulliv@me.com.
²⁷ Alma Mater Studiorum University of Bologna Cornea-Ocular surface Lab and translation research in Ophthalmology IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna Italy. Electronic address: piera.versura@aosp.bo.it.
²⁸ School of Optometry and Vision Science, UNSW, Sydney, Australia. Electronic address: mdpwillcox@gmail.com.

PMID: 41110677
DOI: 10.1016/j.ajo.2025.10.018

Abstract

(Dry eye disease, DED), ,, . (Tear Film & Ocular Surface Society, TFOS) (Dry Eye Workshop, DEWS III) 2017, :",, /, ,." :, ., .OSDI-6, ≥4. (non-invasive breakup time, NIBUT) <10, (≥ 308 mOsm/L >8 mOsm/L), ., , >5;/>9;/≥2mm≥25%, . (,/) (,/,,,//) , , .

Keywords: 亚型; 亚型分类; 定义; 干眼病(DED); 睑板腺功能障碍 (MGD); 睑缘炎; 诊断; 鉴别诊断.

Publication types

Review

Grants and funding

P30 EY014801/EY/NEI NIH HHS/United States