Unmasking prurigo nodularis endotypes: Dominant role of IL 31 dysregulation

J Eur Acad Dermatol Venereol. 2026 Feb;40(2):e176-e178. doi: 10.1111/jdv.70137. Epub 2025 Oct 22.

Authors

Sonja Ständer¹, Emma Guttman-Yassky², Gil Yosipovitch³, Henning Wiegmann¹, Dieter Metze¹, Madeline Kim², Ester Del Duca², Kent Bondensgaard⁴, John F Paolini⁴; LOTUS‐PN Investigators Group

Affiliations

¹ Pruritus Medicine Section, Department of Dermatology, and Center for Chronic Pruritus (KCP), University Hospital of Münster, Münster, Germany.
² Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York City, New York, USA.
³ Dr. Phillip Frost Department of Dermatology & Cutaneous Surgery, Miller School of Medicine, University of Miami, Miami, Florida, USA.
⁴ Kiniksa Pharmaceuticals Corp, Lexington, Massachusetts, USA.

PMID: 41123301
DOI: 10.1111/jdv.70137

No abstract available

Keywords: OSMR pathway; chronic prurigo; neuroimmune itch pathways; prurigo nodularis; pruritus.

Publication types

Letter

Grants and funding

Kiniksa Pharmaceuticals