Treatment Strategies for Prevention of Atopic Dermatitis

Immunol Allergy Clin North Am. 2025 Nov;45(4):515-534. doi: 10.1016/j.iac.2025.06.004. Epub 2025 Jul 28.

Abstract

Key strategies for atopic dermatitis prevention have been reviewed, which include maternal dietary modifications, breastfeeding, and early allergen introduction to promote immune tolerance. Maintaining skin barrier integrity is critical, with early emollient use in high-risk infants showing promise, but clarity on optimal emollient type, duration, and window of intervention is needed. Probiotic supplementation in pregnancy, lactation, and in early life, as well as infant dietary diversity from an early age may be beneficial. Evidence for omega-3 and vitamin D supplementation is inconclusive. Microbiome-targeted therapies are emerging areas for future research but have yet to reach clinical practice.

Keywords: Allergy prevention; Atopic dermatitis; Eczema; Treatment.

Publication types

  • Review

MeSH terms

  • Breast Feeding
  • Dermatitis, Atopic* / etiology
  • Dermatitis, Atopic* / immunology
  • Dermatitis, Atopic* / prevention & control
  • Dermatitis, Atopic* / therapy
  • Dietary Supplements
  • Fatty Acids, Omega-3
  • Female
  • Humans
  • Immune Tolerance
  • Infant
  • Pregnancy
  • Probiotics / therapeutic use
  • Vitamin D

Substances

  • Vitamin D
  • Fatty Acids, Omega-3