Abstract
BALB/c mice immunized with myeloma proteins 315 or 460 made antibodies to the individually specific ("idiotypic") determinants of these proteins and suppressed growth of the corresponding transplanted tumor cells (MOPC-315 or MOPC-460). Stable, variant MOPC-315 tumors that produce only the light chain of protein 315 grew in several of the mice immunized with this protein, probably because the anti-idiotypic immune response selects against those myeloma cells that form the intact myeloma protein.
MeSH terms
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Animals
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Antibody Specificity
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Antigen-Antibody Reactions
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Antigens*
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Dinitrophenols
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Epitopes
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Immune Sera
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Immunization
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Immunodiffusion
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Immunoglobulin A
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Iodine Isotopes
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Mice
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Mice, Inbred Strains
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Multiple Myeloma / immunology
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Myeloma Proteins / metabolism*
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Neoplasm Transplantation
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Neoplasms, Experimental / immunology
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Rabbits / immunology
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Skin Transplantation
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Time Factors
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Transplantation Immunology*
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Transplantation, Homologous
Substances
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Antigens
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Dinitrophenols
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Epitopes
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Immune Sera
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Immunoglobulin A
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Iodine Isotopes
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Myeloma Proteins