Real-world multicenter analysis of CPX-351 efficacy in patients aged less than 60 years with secondary acute myeloid leukemia

Calogero Vetro; Bruno Garibaldi; Francesco Grimaldi; Patrizia Chiusolo; Carla Filì; Carola Riva; Valeria Cardinali; Marinunzia Franciosa; Federica Pilo; Raffaele Palmieri; Lorenzo Esposito; Diego Menotti; Salvatore Perrone; Antonino Mulè; Caterina Alati; Ernesto Vigna; Michela Dargenio; Giulia De Luca; Alessandra Sperotto; Ilaria Tanasi; Cristina Papayannidis; Matteo Molica; Paola Minetto; Giorgia Battipaglia; Mara Memoli; Prassede Salutari; Lorenzo Brunetti; Elisabetta Todisco; Ivana Lotesoriere; Alessandro Isidori; Giuseppe Alberto Palumbo; Mario Annunziata; Michele Gottardi; Massimo Gentile; Maria Paola Martelli; Debora Capelli; Massimo Martino; Marco Rossi; Felicetto Ferrara; Adriano Venditti; Claudio Romani; Sara Galimberti; Anna Candoni; Luana Fianchi; Livio Pagano; Giovanni Marconi; Roberto Massimo Lemoli; Francesco Di Raimondo; Atto Billio; Fanny Erika Palumbo; Fabrizio Pane; Andrea Duminuco; Fabio Guolo

doi:10.1038/s41408-025-01394-7

Real-world multicenter analysis of CPX-351 efficacy in patients aged less than 60 years with secondary acute myeloid leukemia

Blood Cancer J. 2025 Oct 26;15(1):181. doi: 10.1038/s41408-025-01394-7.

Authors

Calogero Vetro^#¹, Bruno Garibaldi^#², Francesco Grimaldi³, Patrizia Chiusolo⁴, Carla Filì⁵, Carola Riva⁶, Valeria Cardinali⁷, Marinunzia Franciosa⁸, Federica Pilo⁹, Raffaele Palmieri¹⁰, Lorenzo Esposito^{11

12}, Diego Menotti¹³, Salvatore Perrone¹⁴, Antonino Mulè¹⁵, Caterina Alati¹⁶, Ernesto Vigna¹⁷, Michela Dargenio¹⁸, Giulia De Luca¹⁹, Alessandra Sperotto²⁰, Ilaria Tanasi²¹, Cristina Papayannidis²², Matteo Molica²³, Paola Minetto²⁴, Giorgia Battipaglia¹¹, Mara Memoli¹¹, Prassede Salutari¹⁹, Lorenzo Brunetti^{25

26}, Elisabetta Todisco²⁷, Ivana Lotesoriere²⁷, Alessandro Isidori²⁸, Giuseppe Alberto Palumbo^{2

29}, Mario Annunziata¹², Michele Gottardi²⁰, Massimo Gentile^{17

30}, Maria Paola Martelli⁷, Debora Capelli²⁶, Massimo Martino¹⁶, Marco Rossi²³, Felicetto Ferrara¹², Adriano Venditti¹⁰, Claudio Romani⁹, Sara Galimberti⁸, Anna Candoni³¹, Luana Fianchi³², Livio Pagano³², Giovanni Marconi³³, Roberto Massimo Lemoli^{6

24}, Francesco Di Raimondo², Atto Billio¹, Fanny Erika Palumbo³⁴, Fabrizio Pane¹¹, Andrea Duminuco², Fabio Guolo^{6

24}

Affiliations

¹ Hematology and Bone Marrow Transplantation Unit, Hospital of Bolzano (SABES-Azienda Sanitaria dell'Alto Adige), Teaching Hospital of Paracelsus Medical University, Bolzano, Italy.
² Division of Haematology, A.O.U. Policlinico G.Rodolico - S. Marco, Catania, Italy.
³ Department of Clinical Medicine and Surgery, Hematology Division, University of Napoli Federico II, Napoli, Italy. grimaldi.francesco@gmail.com.
⁴ Ematologia e Trapianto, Dipartimento di Scienze di Laboratorio ed Ematologiche, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy.
⁵ Division of Hematology and Stem Cell Transplantation, University Hospital ASUFC, Udine, Italy.
⁶ Clinic of Hematology, Department of Internal Medicine (DiMI), University of Genoa, Genoa, Italy.
⁷ Institute of Hematology, Centro Ricerche Emato-Oncologiche (CREO), Ospedale S. Maria della Misericordia, University of Perugia, Perugia, Italy.
⁸ Division of Haematology, A.O.U. Pisana, U.O. Ematologia, Pisa, Italy.
⁹ U.O.C. Ematologia e Trapianto di cellule staminali emopoietiche, ARNAS Brotzu, Cagliari, Italy.
¹⁰ Hematology, Department of Biomedicine and Prevention, University of Tor Vergata, Rome, Italy.
¹¹ Department of Clinical Medicine and Surgery, Hematology Division, University of Napoli Federico II, Napoli, Italy.
¹² Division of Hematology, AORN Cardarelli Hospital, Naples, Italy.
¹³ UOC Immunoematologia e Trasfusionale, Azienda Sanitaria Territoriale Pesaro Urbino, Pesaro, Italy.
¹⁴ Hematology, Polo Universitario Pontino, Sapienza, Via A. Canova S.M. Goretti Hospital, Latina, Italy.
¹⁵ Oncohematology Unit - AO Villa Sofia - Cervello, Palermo, Italy.
¹⁶ Stem Cell Transplantation and Cellular Therapies Unit (CTMO), Department of Hemato-Oncology and Radiotherapy, Grande Ospedale Metropolitano Bianchi-Melacrino-Morelli, Reggio Calabria, Italy.
¹⁷ Hematology Unit, AO of Cosenza, Cosenza, Italy.
¹⁸ Division of Haematology, A.O. Vito Fazi, Lecce, Italy.
¹⁹ UOC Ematologia Clinica, Ospedale Civile Santo Spirito, Pescara, Italy.
²⁰ Onco Hematology, Department of Oncology, Veneto Institute of Oncology IOV-IRCCS, Castelfranco Veneto, Italy.
²¹ Hematology Unit, Department of Engineering for Innovation Medicine, University of Verona, Verona, Italy.
²² IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia "Seràgnoli", Bologna, Italy.
²³ Department of Hemato-Oncology, AOU R Dulbecco, Catanzaro, Italy.
²⁴ Hematology Division, IRCCS Ospedale Policlinico San Martino, Genova, Italy.
²⁵ Dipartimento di Scienze Cliniche e Molecolari, Università Politecnica delle Marche, Ancona, Italy.
²⁶ Clinica di Ematologia, Azienda Ospedaliero Universitaria delle Marche, Ancona, Italy.
²⁷ SC Ematologia, Ospedale Busto Arsizio, ASST Valle Olona, Varese, Italy.
²⁸ Haematology and Stem Cell Transplant Center, Azienda Ospedaliera Ospedali Riuniti Marche Nord (AORMN), Pesaro, Italy.
²⁹ Dipartimento di Scienze Mediche, Chirurgiche e Tecnologie Avanzate "G.F. Ingrassia", University of Catania, Catania, Italy.
³⁰ Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, Italy.
³¹ Section of Hematology, Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy.
³² Fondazione Policlinico Universitario A. Gemelli, IRCCS - Università Cattolica del Sacro Cuore, Roma, Italy.
³³ UO Ematologia, Ospedale S. Maria delle Croci, Ravenna, Italy.
³⁴ Division of Haematology, A.O.U. Policlinico G.Rodolico - S. Marco, Catania, Italy. fannypalumbo@gmail.com.

^# Contributed equally.

No abstract available

Publication types

Letter