Beta-Caryophyllene Mitigates Oxidative Stress in Skin Fibroblasts by Targeting mTOR, Akt, and MAPK Signaling

Cell Biochem Biophys. 2026 Mar;84(1):1087-1099. doi: 10.1007/s12013-025-01926-9. Epub 2025 Oct 29.

Chanachinat Booraphet¹, Wanwipha Woonnoi¹, Wiwit Suttithumsatid^{2

3}, Supita Tanasawet¹, Nobuhiro Zaima^{4

5}, Wanida Sukketsiri⁶

¹ Division of Health and Applied Sciences, Faculty of Science, Prince of Songkla University, Hat Yai, 90110, Songkhla, Thailand.
² Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Songkhla, 90110, Thailand.
³ Phytomedicine and Pharmaceutical Biotechnology Excellence Center, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Songkhla, 90110, Thailand.
⁴ Graduate School of Agriculture, Kindai University, Nara, Japan.
⁵ Agricultural Technology and Innovation Research Institute, Kindai University, Nara, Japan.
⁶ Division of Health and Applied Sciences, Faculty of Science, Prince of Songkla University, Hat Yai, 90110, Songkhla, Thailand. wanida.su@psu.ac.th.

No abstract available

Keywords: Human dermal fibroblast; Inflammation; Oxidative stress; Skin aging; Vitamin d.

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