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. 2025 Nov 5:1-6.
doi: 10.1080/14786419.2025.2581220. Online ahead of print.

New aromatic butenolides from the plant endophytic fungus Malbranchea umbrina D16

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New aromatic butenolides from the plant endophytic fungus Malbranchea umbrina D16

Xian-An Chen et al. Nat Prod Res. .

Abstract

Five aromatic butenolides including two new ones, malbranketons A and B (1 and 2), were obtained from the Euphorbia wallichii-derived endophytic fungus Malbranchea umbrina D16. Their structures including the absolute configuration were elucidated by NMR, HRMS, ECD, and X-Ray data. All compounds were examined for their cytotoxic activities against four tumour cell lines H1975, Panc-1, A549, and 22RV-1, but without effects (IC50 > 20 μM).

Keywords: Aromatic butanolide; Endophytic fungi; Malbranchea umbrina D16; Malbranketon A; Malbranketon B.

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