HistENCODE: a proposed project to decipher functional interactions among and between histone PTMs

Abstract

Twenty-five years after the histone code hypothesis proposed that combinations of histone post-translational modifications (PTMs) direct gene regulation, fundamental questions remain unresolved. Here, I outline a call for a multi-laboratory initiative, termed HistENCODE, to systematically decipher functional relationships between histone PTMs via direct mutagenesis of histone N-terminal tail residues.