Reticulostimulating properties of killed vaccines of anaerobic coryneforms and other organisms

J Natl Cancer Inst. 1977 Dec;59(6):1697-708. doi: 10.1093/jnci/59.6.1697.


Vaccines prepared from 115 strains of anaerobic coryneforms and other organisms were tested in mice for their reticulostimulating ability as judged by the degree of spleen hypertrophy produced after ip injection. Almost all vaccines caused a statistically significant increase in spleen weight, but the ability to produce spleen ratios (test mean wt:control mean wt) of 4 or more was confined to Propionibacterium acnes and P. avidum strains. P. acnes, type II, gave high spleen ratios more frequently than strains of any other type.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Actinomycetales / immunology*
  • Animals
  • Antigens, Bacterial
  • Bacterial Vaccines / pharmacology*
  • Cross Reactions
  • Female
  • Male
  • Mice
  • Mice, Inbred CBA
  • Mice, Inbred Strains
  • Mononuclear Phagocyte System / immunology*
  • Organ Size
  • Propionibacterium / immunology*
  • Propionibacterium acnes / immunology*
  • Species Specificity
  • Spleen / anatomy & histology


  • Antigens, Bacterial
  • Bacterial Vaccines