A green approach to 2-arylquinolines via palladium-catalysed C-H activation

RSC Adv. 2025 Nov 4;15(50):42588-42593. doi: 10.1039/d5ra05924k. eCollection 2025 Oct 31.

Abstract

A mild, palladium-catalyzed C-H activation enables direct, sustainable synthesis of 2-arylquinolines from simple allyl amines, with up to 64% yield; green chemistry metrics highlight its superior atom economy and reduced environmental impact compared to conventional methods.