Terlipressin for Hepatorenal Syndrome in Patients With Early-Stage Acute-on-Chronic Liver Failure

Liver Int. 2025 Dec;45(12):e70399. doi: 10.1111/liv.70399.

Abstract

Background & aims: Hepatorenal syndrome-acute kidney injury (HRS-AKI) is a life-threatening complication of decompensated cirrhosis. The US Food and Drug Administration approved terlipressin use for HRS-AKI based on the CONFIRM study, which demonstrated a significant improvement in HRS reversal with terlipressin versus placebo. The label notes elevated risk of respiratory failure in patients with volume overload or acute-on-chronic liver failure (ACLF) grade 3 and limited benefit when serum creatinine (SCr) exceeds 5 mg/dL.

Methods: We performed a post hoc analysis of CONFIRM excluding patients with ACLF grade 3 or SCr ≥ 5 mg/dL. This allowed us to assess the efficacy and safety of terlipressin in a population where the benefit-to-risk profile is more favourable. Efficacy outcomes included HRS reversal, renal replacement therapy (RRT), liver transplantation (LT), RRT-free survival, LT-free survival and overall survival. Changes in SCr, Model for End Stage Liver Disease (MELD) and sodium were also assessed.

Results: HRS reversal occurred in 43% (60/141) of patients with terlipressin versus 17% (13/75) with placebo (p < 0.001). Terlipressin was associated with significantly larger reductions (vs. placebo) in SCr (p < 0.001) and increases in serum sodium (p < 0.001). Importantly, LT rates were similar even though MELD scores decreased. 90-day survival was similar between treatment arms. Notably, selecting patients with a favourable benefit-to-risk profile led to a similar incidence of respiratory failure between treatment arms (11% with terlipressin vs. 7% with placebo; p = 0.360).

Conclusions: In patients with HRS-AKI without baseline ACLF grade 3 or SCr ≥ 5 mg/dL, terlipressin improved clinical outcomes and was not associated with an increased risk of respiratory failure.

Trial registration: CONFIRM, ClinicalTrials.gov identifier: NCT02770716.

Keywords: acute kidney injury; ascites; cirrhosis; creatinine; portal hypertension; respiratory failure.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Acute-On-Chronic Liver Failure* / complications
  • Acute-On-Chronic Liver Failure* / mortality
  • Aged
  • Creatinine / blood
  • Double-Blind Method
  • Female
  • Hepatorenal Syndrome* / drug therapy
  • Hepatorenal Syndrome* / etiology
  • Hepatorenal Syndrome* / mortality
  • Humans
  • Liver Transplantation / statistics & numerical data
  • Lypressin* / analogs & derivatives
  • Lypressin* / therapeutic use
  • Male
  • Middle Aged
  • Renal Replacement Therapy
  • Terlipressin* / therapeutic use
  • Treatment Outcome
  • Vasoconstrictor Agents* / adverse effects
  • Vasoconstrictor Agents* / therapeutic use

Substances

  • Terlipressin
  • Vasoconstrictor Agents
  • Lypressin
  • Creatinine

Associated data

  • ClinicalTrials.gov/NCT02770716