Immune system, inflammatory response, and regulated cell death in breast cancer research (Review)

Oncol Rep. 2026 Jan;55(1):11. doi: 10.3892/or.2025.9016. Epub 2025 Nov 7.

Abstract

Breast cancer (BC) ranks among the most prevalent malignant tumors in female patients. It represents a longstanding challenge to medical professionals in terms of diagnosis and treatment. Exploring BC pathogenesis offers insight into its complexity and facilitates the exploration of more effective treatment strategies. The present review aimed to describe the involvement of the immune system, inflammatory response and regulated cell death in BC development, offering avenues for novel therapeutic strategies against BC. Identifying novel treatment methods is key for enhancing the prognosis of patients with BC.

Keywords: breast cancer; immune system; inflammatory response; regulated cell death; therapy.

Publication types

  • Review

MeSH terms

  • Breast Neoplasms* / immunology
  • Breast Neoplasms* / pathology
  • Female
  • Humans
  • Immune System* / immunology
  • Inflammation* / immunology
  • Inflammation* / pathology
  • Prognosis
  • Regulated Cell Death* / immunology
  • Tumor Microenvironment / immunology