Boosting dopamine: Following the lineage toward Parkinson's repair

Clare L Parish

doi:10.1016/j.stem.2025.09.012

Boosting dopamine: Following the lineage toward Parkinson's repair

Cell Stem Cell. 2025 Nov 6;32(11):1635-1636. doi: 10.1016/j.stem.2025.09.012.

Author

Clare L Parish¹

Affiliation

¹ The Florey Institute of Neuroscience and Mental Health, Parkville, VIC 3052, Australia. Electronic address: clare.parish@florey.edu.au.

PMID: 41202798
DOI: 10.1016/j.stem.2025.09.012

Abstract

Low yields of dopamine neurons in human stem cell-derived neural grafts limit their potential for treating Parkinson's disease. Zhang et al.¹ develop a new three-dimensional differentiation method, informed and refined through careful clonal linage tracing of donor cells post-transplantation, to improve dopamine neuron purity of grafts, eliminating unwanted, off-target populations.

MeSH terms

Cell Differentiation
Cell Lineage*
Dopamine* / metabolism
Dopaminergic Neurons* / cytology
Dopaminergic Neurons* / metabolism
Dopaminergic Neurons* / transplantation
Humans
Neural Stem Cells / cytology
Neural Stem Cells / transplantation
Parkinson Disease* / pathology
Parkinson Disease* / therapy

Substances

Dopamine