Molecular glues: A new path to the world of the unattainable

Abstract

Molecular glues (MGs) are a new class of small molecules that can modulate protein-protein interactions, leading to selective protein degradation, stabilization or activation. This breakthrough opens new possibilities for treating diseases such as cancer and neurodegenerative disorders. By targeting proteins previously considered "undruggable" due to the lack of conventional binding pockets, MGs are transforming drug discovery and delivery. By modifying protein interactions, MGs have potential not only in oncology but also in other biomedical applications. This review delves into how MGs induce targeted protein interactions, describes some of their therapeutic uses and recent advancements in this rapidly evolving field.

Keywords: Molecular glues; Protein-protein interactions (PPIs); Targeted protein degradation.