Effects of Acute Fish Oil Supplementation on Muscle Function and Soreness After Eccentric Contraction-Induced Muscle Damage

Nutrients. 2025 Oct 29;17(21):3408. doi: 10.3390/nu17213408.

Abstract

Purpose: The primary aim of this study was to determine the efficacy of acute fish oil (FO) supplementation on indices of exercise-induced muscle damage (EIMD) in young healthy adults.

Methods: Twenty-two healthy young male and females were randomly assigned to two experimental groups: fish oil (FO) or placebo control (CON). Participants performed a muscle damage protocol consisting of 10 sets of 10 plyometric drop jumps. Vertical jump height, isometric maximal voluntary contraction (MVC) torque, and systemic inflammation markers were assessed at pre-exercise, immediately post (post-0), post-24, post-48, and post-72 h.

Results: Vertical jump performance and quadriceps peak torque significantly decreased in the CON group at post-0, 24, and 48 h (p < 0.05), while FO group recovered to baseline levels by post 48 h. Hamstring peak torque reductions recovered in the FO group at post-48 h but remained suppressed in the CON group until post-72 h (p < 0.05). Muscle soreness was significantly higher in the CON group compared to the FO group at post-48 h (p < 0.05). Systemic TNF-α levels significantly increased from baseline to post-0, 24, and 48 h in both groups (p < 0.05), with the CON group showing a trend toward incomplete recovery (p = 0.065).

Conclusions: Our findings indicate that acute FO administration may modestly aid muscle recovery and reduce muscle soreness following EIMD in healthy young adults while the overall impact may be limited.

Keywords: fish oil; inflammation; muscle damage; muscle function; muscle soreness.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Dietary Supplements*
  • Female
  • Fish Oils* / administration & dosage
  • Fish Oils* / pharmacology
  • Humans
  • Male
  • Muscle Contraction* / drug effects
  • Muscle Strength / drug effects
  • Muscle, Skeletal* / drug effects
  • Muscle, Skeletal* / physiopathology
  • Myalgia* / drug therapy
  • Myalgia* / etiology
  • Myalgia* / physiopathology
  • Torque
  • Young Adult

Substances

  • Fish Oils