Drug Dosages and Interactions: Standardizations in Dental Practice

Dent Clin North Am. 2026 Jan;70(1):225-242. doi: 10.1016/j.cden.2025.07.015. Epub 2025 Sep 5.

Abstract

This article reviews the existing guidelines (or the lack thereof) for standardization of drug dosages and indications across global dental institutions and practices. Discrepancies related to drug dosing include, but are not limited to, the volume of the local anesthetic cartridge, antibiotic dose administration preoperatively and postoperatively, the need for antibiotic administration in dentistry, and drugs deemed safe in pregnancy and lactation.

Keywords: Antibiotic resistance; Dental local anesthesia; Dental sedation; Drug dosages in dentistry; Drug interactions in dentistry; Opioids; Pediatric dosage in dentistry; Pregnancy drug category.

Publication types

  • Review

MeSH terms

  • Anesthesia, Dental / standards
  • Anti-Bacterial Agents / administration & dosage
  • Dental Care* / standards
  • Drug Interactions
  • Female
  • Humans
  • Practice Guidelines as Topic
  • Pregnancy

Substances

  • Anti-Bacterial Agents