Review of Colonic Pseudo-obstruction

Surg Clin North Am. 2026 Feb;106(1):153-168. doi: 10.1016/j.suc.2025.08.014. Epub 2025 Sep 17.

Abstract

Colonic pseudo-obstruction is often secondary to disturbances in the enteric nervous system and can be difficult to treat definitively. Treatment options primarily focus on conservative measures and medical management with acetylcholinesterase inhibitors. Surgeons should feel comfortable with endoscopic decompression when necessary. Rarely, acute colonic pseudo-obstruction will require surgery because of impending perforation, and it is imperative that surgeons recognize indications for operative intervention.

Keywords: Acute colonic pseudo-obstruction; Chronic intestinal pseudo-obstruction; Ogilvie.

Publication types

  • Review

MeSH terms

  • Cholinesterase Inhibitors / therapeutic use
  • Colonic Pseudo-Obstruction* / diagnosis
  • Colonic Pseudo-Obstruction* / etiology
  • Colonic Pseudo-Obstruction* / surgery
  • Colonic Pseudo-Obstruction* / therapy
  • Decompression, Surgical
  • Humans

Substances

  • Cholinesterase Inhibitors