Objective: To summarize recent research progress in hydrogel-based growth factors for treatment of intervertebral disc degeneration (IDD).
Methods: The relevant literature on hydrogel-based growth factors for IDD treatment at home and abroad was extensively reviewed, and their advantages and therapeutic effects in repairing IDD were analyzed and summarized.
Results: Hydrogels exhibit high hydration, biocompatibility, and biodegradability, enabling targeted delivery and sustained release of growth factors such as growth differentiation factors and transforming growth factors. This facilitates enhanced efficacy in promoting cell proliferation, extracellular matrix synthesis, and reducing inflammatory responses. Consequently, hydrogels demonstrate broad application prospects in the repair of IDD.
Conclusion: Research on hydrogel-based growth factors for treating IDD demonstrates advantages such as avoiding disc damage caused by repeated injections and controlling growth factor release concentrations. However, drawbacks include the limited variety of loaded growth factors and the need to verify the long-term stability and biocompatibility of hydrogels. Therefore, further research is required on aspects such as the types of loaded growth factors and the long-term stability and biocompatibility of hydrogels to establish an experimental foundation for their clinical application.
目的: 总结近年来水凝胶搭载生长因子治疗椎间盘退变（intervertebral disc degeneration，IDD）研究进展。.
方法: 广泛查阅国内外相关文献，对水凝胶搭载生长因子治疗IDD的优势和效果进行总结分析。.
结果: 水凝胶具有高水合性、生物相容性和可生物降解性，能够靶向递送和持续释放生长因子，如生长分化因子、转化生长因子等，能够更好地发挥生长因子促进细胞增殖、细胞外基质合成及减少炎症反应等作用，在IDD修复中展现出广阔的应用前景。.
结论: 水凝胶搭载生长因子治疗IDD具有避免反复注射造成椎间盘损伤和控制生长因子释放浓度等优势，但是也存在搭载的生长因子种类单一以及水凝胶的长期稳定性、生物相容性尚待验证等不足，需从搭载生长因子种类和水凝胶的长期稳定性、生物相容性等方面进一步研究，为其临床应用奠定实验基础。.
Keywords: Intervertebral disc degeneration; growth factors; hydrogel; regeneration; repair.