Safety Assessment of Anhydrogalactose, Anhydroglucitol, Anhydroxylitol, Arabinose, Psicose, Saccharide Hydrolysate, and Saccharide Isomerate as Used in Cosmetics

Int J Toxicol. 2025 Dec;44(4_suppl):93S-120S. doi: 10.1177/10915818251384580. Epub 2025 Nov 16.

Abstract

The Expert Panel for Cosmetic Ingredient Safety (Panel) reviewed the safety of 7 saccharides/saccharide derivatives as used in cosmetic products; all of these ingredients are reported to function as skin-conditioning agents-humectant in cosmetics. The Panel reviewed data relevant to the safety of these ingredients in cosmetic formulations and concluded that Anhydrogalactose, Anhydroglucitol, Anhydroxylitol, Arabinose, Psicose, Saccharide Hydrolysate, and Saccharide Isomerate are safe in cosmetics in the present practices of use and concentration described in this safety assessment.

Keywords: Anhydrogalactose; Anhydroglucitol; Anhydroxylitol; Arabinose; Cosmetic Ingredient Review; Cosmetics; Expert Panel for Cosmetic Ingredient Safety; Psicose; Saccharide Hydrolysate; Saccharide Isomerate; Safety.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Arabinose / chemistry
  • Arabinose / toxicity
  • Consumer Product Safety
  • Cosmetics* / chemistry
  • Cosmetics* / toxicity
  • Deoxyglucose / analogs & derivatives
  • Deoxyglucose / chemistry
  • Deoxyglucose / toxicity
  • Galactose / analogs & derivatives
  • Galactose / chemistry
  • Galactose / toxicity
  • Humans
  • Isomerism
  • Lactose / analogs & derivatives
  • Lactose / chemistry
  • Lactose / toxicity
  • Risk Assessment
  • Xylitol / chemistry
  • Xylitol / toxicity
  • Xylose / analogs & derivatives
  • Xylose / chemistry
  • Xylose / toxicity

Substances

  • 1,5-anhydroglucitol
  • Arabinose
  • Cosmetics
  • Deoxyglucose
  • Galactose
  • Lactose
  • Xylitol
  • Xylose