Unmasking the genetic double agents of hyperglycemia: Mendelian randomization in endotheli-hell espionage

Shivangi Pande; Fahimeh Varzideh; George Ishak; Pasquale Mone; Urna Kansakar; Stanislovas S Jankauskas; Gaetano Santulli

doi:10.1016/j.atherosclerosis.2025.120506

Unmasking the genetic double agents of hyperglycemia: Mendelian randomization in endotheli-hell espionage

Atherosclerosis. 2025 Nov:410:120506. doi: 10.1016/j.atherosclerosis.2025.120506. Epub 2025 Nov 15.

Authors

Shivangi Pande¹, Fahimeh Varzideh¹, George Ishak¹, Pasquale Mone², Urna Kansakar¹, Stanislovas S Jankauskas¹, Gaetano Santulli³

Affiliations

¹ Department of Medicine, Division of Cardiology, Wilf Family Cardiovascular Research Institute, Einstein Institute for Aging Research, Albert Einstein College of Medicine, New York City, NY, USA.
² Department of Medicine, Division of Cardiology, Wilf Family Cardiovascular Research Institute, Einstein Institute for Aging Research, Albert Einstein College of Medicine, New York City, NY, USA; Casa di Cura Montevergine, Mercogliano, Avellino, Italy.
³ Department of Medicine, Division of Cardiology, Wilf Family Cardiovascular Research Institute, Einstein Institute for Aging Research, Albert Einstein College of Medicine, New York City, NY, USA; Department of Advanced Biomedical Sciences, "Federico II" University, Naples, Italy; International Translational Research and Medical Education (ITME) Consortium, Academic Research Unit, Naples, Italy; Department of Molecular Pharmacology, Einstein-Mount Sinai Diabetes Research Center (ES-DRC), Fleischer Institute for Diabetes and Metabolism (FIDAM), Albert Einstein College of Medicine, New York City, NY, USA. Electronic address: gsantulli001@gmail.com.

PMID: 41248964
DOI: 10.1016/j.atherosclerosis.2025.120506

No abstract available

Keywords: Cardiometabolic health; Diabetes; Endothelial dysfunction; Mendelian randomization; Mendelian studies; Precision medicine; Risk prediction.

Publication types

Editorial